Chairperson Dr. Andrea Polli
PublicationsThe vision of the Pain in Motion Biology research line is to pioneer a deeper understanding of how epigenetic modifications influence and modulates persistent pain and similar disorders where pain plays a major part such as ME/CFS and Long-COVID. By investigating the molecular underpinnings of biological mechanisms, we aim to challenge the traditional views of chronic pain and establish a more holistic, personalized approach to treatment. We envision a future where the combination of genomic data, patient-specific profiles, lifestyle interventions and metabolic therapies can lead to more effective, tailored therapeutic strategies. Ultimately, our goal is to bridge the gap between basic research and clinical application, improve the understanding of molecular underlying mechanisms, and provide patients with better treatment options. Through collaborative research and training the next generation of pain scientists, we aim to make significant contributions to the fields of pain management, epigenetics, and neurobiology.
The Pain in Motion Biology research line is centered on understanding the complex biological mechanisms underlying chronic pain and related disorders, with a particular focus on the role of epigenetics and DNA methylation in shaping pain responses. Our interdisciplinary approach involves a combination of clinical studies and molecular biology, and advanced molecular and immunological techniques to explore how genetic, environmental, and lifestyle factors contribute to the development and persistence of chronic pain conditions, such as chronic widespread pain and ME/CFS, but also in populations with specific medical conditions like breast cancer. Through this work, we aim to identify biomarkers and therapeutic targets that can help improve the diagnosis, management, and treatment of chronic pain syndromes.